P-7: Sperm DNA Assessment as A Tool for Partial Resolver of The Unexplained Infertility Problem

Background: To establish importance of sperm DNA assessment in resolving the unexplained infertility problem. Materials and Methods: This article is based on the careful observation of texts and papers from 2000-2014 about the DNA damage assessment as a significant parameter of sperm function test. Results: Acidic Aniline blue, Sperm Chromatin Dispersion test(SCD), Malondialdehyde concentration, 8-OH dG and total antioxidant capacity (TAC) are tools for studying of sperm packaging density, Sperm Nuclear Matrix Assay and oxidative stress respectively and we can use each of them to clear the dark edges of unexplained infertility in clinical practice. Conclusion: Increased amounts of DNA Fragmentation Index(DFI) and by products of lipid peroxidation and DNA denaturation have reserve proportional to the rate of fertilization and pregnancy rates in the era of spontaneous and assisted pregnancy. The exact prediction of each of this matters requires exact evaluation of the background pathology.